484 New insight of itch mediators and proinflammatory cytokines in epidermolysis bullosa

Epidermolysis bullosa (EB) is a hereditary disorder characterized by mechanical stress-induced blistering. The presence of extracutaneous complications such as cardiomyopathy and renal disease observed in severe EB subtypes the fact that pruritus common symptom across all indicate not only skin fragility but also systemic inflammatory disorder. Our study aims to elucidate basis inflammation seen patients. We analyzed serum samples 20 patients Luminex bead-based cytokine assays enzyme-linked immunosorbent assays. In group itch mediators, levels Th2 cytokines including IL-4, IL-5, IL-13 were elevated (p > 0.05). contrast, TSLP significantly increased = 0.01), IL-31 oncostatin M statistically significant tended be higher than healthy controls. Among proinflammatory IL-1β, IL-6, TNF-α, IL-6 was < 0.01). addition, sIL-2R, HGF, M-CSF, SCGF-β, IL-8, IL-16, IFN-γ, MIF, MIP-1α 0.01, p 0.05, respectively) found patients, whereas TNF-β 0.01) decreased. conclusion, imbalance several mediators identified. Biologics targeting cytokines, which sera considered beneficial treatment option for EB.